Stage of Diabetic nephropathy

Diabetic nephropathy are no symptoms, are not uncomfortable phenomenon in patients with kidney development, but in late, will appear swollen feet, foamy urine, and kidney damage. Early detection of diabetic nephropathy, the best way is to the investigation ofthe nephrotic urine.
Diabetic nephropathy pathology into which? Do the following instructions:
One: increased glomerular filtration rate, renal volume increased renal blood flow,glomerular capillary perfusion pressure and hypertension. Normal glomerular basement membrane and mesangial Recoverable after appropriate treatment.
Two: that is, normal albuminuria period. Glomerular filtration rate is normal or increasedurinary albumin excretion rate is normal (less than 20 micrograms / min or 30 mg / 24 hours), excretion is increased after exercise or stress, eliminate the incentive to return to normal. Glomerular basement membrane thickening, mesangial matrix increase.Multi-normal blood pressure.
Three: early diabetic nephropathy. Generally normal glomerular filtration rate, urinaryalbumin excretion rate consistently higher than normal, mildly elevated blood pressure.Glomerular basement membrane thickening and mesangial matrix increased significantly, existing glomerular nodular and diffuse lesions and small artery glass-like change, and has begun glomerular abandoned. Of patients blood pressure, mildlyelevated, lower blood pressure can be partially reduced urinary albumin excretion.
Four: clinical diabetic nephropathy. A large number of albumin, urinary protein excretionis consistently greater than 0.5 g per 24 hours non-selective proteinuria, severe urinary protein greater than 3.5 g per 24 hours, hypoalbuminemia, edema and hypertension,often accompanied by varying degrees of the quality of nitrogen retention and diabetic retinopathy. Further thickening of the glomerular basement membrane, a further increasein mesangial matrix, glomerular abandoned.
Five: end-stage renal failure. Urinary protein excretion is reduced, abandoned due toglomerular and glomerular filtration rate of less than 10 ml / min, with high blood pressure,hypoalbuminemia, edema, serum creatinine, blood urea nitrogen increased, loss of appetite, nausea and vomiting and anemia, metabolic acidosis, hypocalcemia, andhyperkalemia, secondary uremic neuropathy and cardiomyopathy.