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2011/07/25

Chronic Renal Failure and Muscle Twitch

Patients with early-stage Chronic Renal Failure should get treatment timely so as to prevent the deterioration of disease. Long-time Chronic Renal Failure will lead to serious damage to human body. There are some symptoms such as hypocalcemia, hyperphosphatemia and electrolyte disorder, which can cause muscle pain.
1. Hypocalcaemia
The Cause of Hypocalcaemia:
Patients with Chronic Renal Failure usually have inappetence, vomit, nausea and diarrhea, which can lead to insufficiency of calcium. At the same time, the damage of digestive tract will influence the absorption of calcium. Most calcium is discharged out of human body through urine. This is the main reason for patients with Chronic Renal Failure to cause Hypocalcaemia.
The damage to muscles from Hypocalcaemia:
The most obvious symptom coming from Hypocalcaemia is excessive excitability of nerves and muscles. Calcium Ion has the ability to restrain internal flow of Sodion. When people with Hypocalcaemia, the inhibitory ability decreased, this can lead to decreased threshold of action potential. The repeating stimulations can lead to exciting nerves and muscles such as muscle pain or muscle twitch. Slight Hypocalcaemia usually manifest with finger and toes pain, arms and legs numb or twitch, stabbing pain; when calcium loses more, there will occur tetany; more serious condition can have whole body skeleton spasm and smooth muscle spasm, and respiratory tract can have bronchospasm or even apnea; vasospasm can show headache, angina and Reynolds.
2. Hyperphosphatemia
The cause of Hyperphosphatemia:
When the kidneys are damaged, the glomerular filtration rate will decrease so that the redundant wastes such as phosphorus, serum creatinine and BUN can not be discharged out of human body. As for phosphorus, long-time accumulation in blood can lead to Hyperphosphatemia. Balanced calcium and phosphorus can promote the use of inorganic salt. Silicate can keep the metabolism of Vitamin D and then maintain homeostasis of calcium. High phosphorus can influence the absorption of calcium.
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