Kidney failure led by diabetes is usually more complex and dangerous then other kidney diseases, even after the initiation of dialysis and kidney transplant, diabetics tend to go on much worser than others.
Then how are Diabetes and kidney failure interlinked with each other?
First, Diabetes can cause renal failure. The culprit in the progression into end-stage renal failure is the high blood glucose, which forces the kidneys to work beyond its capacity so as to excrete the excessive sugar out, thus gradually damaging renal capillaries. High blood glucose also slows down blood flow and intensifies blood concentration, causing deposits of excellular matrix in glomeruli and thickening glomerular basilar membrane. Over time, more and more glomeruli are damaged and diffuse glomerular sclerosis develops, causing increasing amount of protein in urine.
Besides, high blood pressure, whether primary or secondary to diabetes, is another important factor that deteriorate kidney condition. Diabetics with high blood pressure usually have a poorer prognosis than others. Another factor that increases chances of getting renal failure is family history of kidney diseases, but the genetic rate varies.
The earliest sign of diabetic kidney disease is microalbuminuria, which refers to protein in urine between 30mg/24h to 300mg/24h. Heavy proteinuria(>3.5 g/24h) and overall swelling usually indicate that the disease has developed into clinical stage and will develop into end-stage renal failure rapidly.
How does diabetes affect the patients at end-stage renal failure?
In end-stage renal failure, patients are faced with both complications of kidney failure(such as vomiting, nausea, poor appetite, swelling and short breath) and diabetic complications(such as heart disease, retinopathy and neuropathy). So the situation is hard to be controlled. Also, due to lowered immunity, diabetics are also more likely to get infections, which, if occurs, can aggravate heart disease and can be life-threatening. Thereby, diabetics on dialysis usually have a poorer prognosisthan other kidney diseases.
Then how are Diabetes and kidney failure interlinked with each other?
First, Diabetes can cause renal failure. The culprit in the progression into end-stage renal failure is the high blood glucose, which forces the kidneys to work beyond its capacity so as to excrete the excessive sugar out, thus gradually damaging renal capillaries. High blood glucose also slows down blood flow and intensifies blood concentration, causing deposits of excellular matrix in glomeruli and thickening glomerular basilar membrane. Over time, more and more glomeruli are damaged and diffuse glomerular sclerosis develops, causing increasing amount of protein in urine.
Besides, high blood pressure, whether primary or secondary to diabetes, is another important factor that deteriorate kidney condition. Diabetics with high blood pressure usually have a poorer prognosis than others. Another factor that increases chances of getting renal failure is family history of kidney diseases, but the genetic rate varies.
The earliest sign of diabetic kidney disease is microalbuminuria, which refers to protein in urine between 30mg/24h to 300mg/24h. Heavy proteinuria(>3.5 g/24h) and overall swelling usually indicate that the disease has developed into clinical stage and will develop into end-stage renal failure rapidly.
How does diabetes affect the patients at end-stage renal failure?
In end-stage renal failure, patients are faced with both complications of kidney failure(such as vomiting, nausea, poor appetite, swelling and short breath) and diabetic complications(such as heart disease, retinopathy and neuropathy). So the situation is hard to be controlled. Also, due to lowered immunity, diabetics are also more likely to get infections, which, if occurs, can aggravate heart disease and can be life-threatening. Thereby, diabetics on dialysis usually have a poorer prognosisthan other kidney diseases.
