Actually all five stages are the process of deteriorating into Chronic Kidney Failure. Stage 4 Chronic Kidney Disease can be called Kidney Failure.
Chronic Kidney Disease deteriorates into stage 4 Kidney Failure is a long-term disease and caused by various pathogenesis. The pathological mechanism is: metabolic wastes can not be discharged out of body and then pile up in human body, which is just like toxicants piling up in human body. Long-time accumulation of metabolic wastes can lead to kidney fibrosis, and then kidney will lose its functions of filtrating blood and discharging metabolic wastes so the kidneys can not producing urine or have little urine. Kidney dysfunction makes the metabolic wastes such as urea nitrogen and Creatinine can not be discharged out of human body. These harmful substances can flow to each body part along with blood and then damage each body system.
Digestive Tract System
People with stage 4 kidney failure will have some symptoms in digestive tract system. If disease damages digestive tract, gastrointestinal mucosa will be stimulated so that symptoms such as nausea, vomit and diarrhea occur. Oral mucosa will also have fester and there will be the smell of ammonia in patients'mouth
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