The clinical manifestations
of chronic renal failure
The first stage:renal function compensatory
stage:Glomerular filtration rate has decrease to 30-60ML/min, as the glomerular
filtration rate of normal guy is 120L/min.During the stage nephron declined about 20%-25%Although renal
reserve capacity has lost.but the excretion of the metabolin and the capability
of balancing the water ,electrolyte and acid-base is still good. so it has no special
performance in clinic. Muscle blood enzyme and blood urea nitrogen alway noemal
or mild rise.
The second stage:azotemia
stage:Glomerular filtration rate has decrease to 25ML/min,nephron declined 50%-70%,as the disfunction of
renal concentration ,nocturia and diuresis appears, varying degrees of
anemia,often has azotemia ,CRE and urea nitrogen increase.It may be tired, anorexia, mild uncomfortable all over the body.
And so on...During the stage if you neglect to protect the renal function or
organism is overburden.it may vomiting seriously, diarrhea,and insufficient of
the blood volume,and then the renal function loss quickly and failure.
The third
stage:kidney failure (early day of the uremia) Glomerular
filtration rate has decrease to 10-15ML/min,nephron
declined about 70%-90%,the renal function is damaged seriously cannot keep the
metabolism and balance he water,electrolyte
and acid-baser.It's impossible to make the
environment in the body stable,so that the RE and urea nitrogen increase
markedly,Concentration and Dilution of Urine disfunction,acidosis,water natrium retention,low
calcium,high phosphorus,high potassium.It
may has Anemia obvious and gastro-intestinal symptoms,such as nausea and
vomiting,and the neuropsychiatric symptoms like,weak and poor attention.
The fourth
stage:uremia Glomerular filtration rate has decrease
below 10-15ML/min,nephron declined more than
90%,this the later period of the chronic renal
failure,the clinical symptoms said above is
more pronounced,much viscera failure all over
the body,as the unbalance of the gastrointestinal tract, nervous
system,cardiovascular, hemopoietic system, respiratory system ,skin ,and
Metabolic System.It may show up as nausea,vomiting, increased blood pressure,be
nervous,dyspnea,...coma in linical.During this stage it needs to rely on the
dialysis to sustain life.It may cause sudden death frequently by
hyperkalemia,encephaledema,pulmonary edema or heart failure.
