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2012/08/07

Blood Purification for Lupus Nephritis

Treatment lupus erythematosus is one involving the multi-system of the body organ, the complexity of the clinical manifestations, the prolonged course of repeated autoimmune diseases. Lupus erythematosus can be divided into two main categories of systemic lupus erythematosus and discoid lupus erythematosus. Subacute cutaneous lupus erythematosus, is a cross between skin lesions of discoid lupus erythematosus and systemic lupus erythematosus. The treatment of lupus erythematosus available plasma replacement method, the following is the introduction of plasma exchange method.

The treatment of lupus erythematosus through plasma exchange: plasma exchange, double filtration. Plasma adsorption: a rapid decline in the blood faster to improve the condition of antibodies and immune complexes, but still a short-term palliative expedient therapy required with the application of hormones and immunosuppressive agents. Concurrent infection, coagulopathy, water and electrolyte imbalance, and other side effects. And expensive.

Treatment of lupus erythematosus, plasma exchange method is suitable for severe lupus erythematosus associated with high levels of circulating immune complexes and acute diffuse proliferative lupus nephritis and glomerular sclerosis in patients with severe.

The treatment of lupus erythematosus, plasma exchange method is the blood of lupus patients, the introduction of a plasmapheresis device, the separated plasma was discarded, and supplement the inevitable fresh plasma or substitutes, such as 4% human serum albumin, and Ringer . Some patients before treatment to help clear soluble immune complexes and some antibodies, to accept this treatment the circulating immune complexes at high levels decreased significantly after treatment, and often get a good recent treatment. Plasmapheresis method in the treatment process prone to infection, coagulation disorders and complications such as water and electrolyte disturbance, this therapy can only be used as short-term adjuvant therapy in lupus treatment, not long-term use. Plasma exchange therapy can only clear the existing plasma immune complexes, but can not prevent these substances generated when treatment with hormones and immunosuppressive agents, in order to ensure safe and reliable treatment method: Each replacement from 1 to 1.5 liters, week 2 liters, minutes 2-4 times, repeat for a course of 2-3 weeks.
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