Dialysis in Diabetic Nephropathy: Pros and Cons

Cons and Pros for dialysis treatment in Diabetic nephropathy? End-stage diabetic nephropathy patients undergoing have two choices of dialysis: long-term hemodialysis and continuous ambulatory peritoneal dialysis. Recently, the vast majority of patients with end-stage diabetic nephropathy to take peritoneal dialysis, because it does not increase the heart load and stress, better control of extracellular fluid volume and hypertension. Also by intraperitoneal injection of insulin, easy to operate, cost savings, but some patients due to long-term peritoneal dialysis absorb a large number of glucose Erzhi obesity and high cholesterolDiabetic with ESRD, which type of dialysis to choose?Patients with diabetic nephropathy to advanced prone to serious deterioration of renal function, and even uremia. Although dialysis treatment is not advanced diabetic nephropathy in patients with the best treatment, but if early, long-term dialysis treatment can greatly improve the survival rate of patients. When serum creatinine in the 350-440umol / L should be prepared to vascular pathways; when serum creatinine reached 600umol / L or more, you can start dialysis treatment. Clinical in the end is to choose hemodialysis or peritoneal dialysis should be selected according to the disease and the specific conditions.Hemodialysis.In diabetic nephropathy patients on long-term hemodialysis patients, 1-year survival rate of more than 80%. Older, serious condition acceptable to the dialysis treatment. Dialysis in advance, less uremic complications; where the pre-dialysis and dialysis process, better control of blood pressure, attention to fluid balance, to ensure a reasonable nutrition, the survival rate of patients will improve. Hemodialysis process can also be some problems, such as poor vascular pathways, large fluctuations in blood pressure, worsening retinopathy and even blindness and a variety of cardiovascular complications.

[Peritoneal dialysis]1-year survival rate of peritoneal dialysis in diabetic nephropathy was 80% to 90%. Its main advantages are:① cardiovascular system is more stable, better blood pressure control.② to avoid the path of blood vessels.(3) through the abdomen, and injection of insulin, blood sugar control better.The retinopathy can be stable improvement.(5) PD operation is more convenient to patients themselves.⑥ in the high molecular substances cleared.Its shortcomings: 1-prone abdominal infection after infection, easy to shadow noon dialysis effect.The peritoneal dialysis daily loss of protein l0g to pay attention to protein intake.In summary, can not be advanced diabetic nephropathy in kidney transplant ambulatory continuous peritoneal dialysis results better than hemodialysis.  
Considering  peritoneal dialysis, dialysate glucose was partially absorbed by hypertonic dialysate induced hyperosmolar coma, so pay attention to the use of insulin dose adjustment, while avoiding hypoglycemia. However, the possibility of peritonitis in peritoneal dialysis when compared with non-diabetic patients, should pay close attention to actively prevent infection. Dialysis costs are high, the patient's body is even more painful. Is there a treatment more effective and more to reduce the suffering of the patient? 
The answer is yes. after painstaking research, the original micro-based traditional Chinese medicine penetration therapy.
 Related article:
How do Diabetics with High Creatinine Keep away from Dialysis

Is Dialysis only Choice When Creatinine is High in Diabetics

In recent years,incidence of Diabetes and hypertension increased significantly i coupled with the arrival of an aging society. The elderly renal function itself is a downward trend in the role of various etiologies, renal function is more easily damaged. Easy to overlook a lot of patients have symptoms of kidney disease before the knowledge of the kidneys and kidney disease, little is known about or nothing about, so that kidney disease has shown. Patients disapprove, of these symptoms is fatigue due to rest for some time will heal. There are still some patients, due to economic conditions, the disease can have a delaying tactics, less than a last resort not the hospital. Whether it is inadvertently overlooked, or the indifference of the disease, depicting disease in slow development of deterioration, and eventually developed into uremia uremia is a serious kidney disease, most doctors recommend dialysis, then, under what circumstances must do dialysis do?

   Indications to rapidly start dialysis in chronic renal failure:
    (1) drugs can not control the hyperkalemia ≥ 6.5mmol / L;

    (2) sodium retention, oliguria, anuria, high degree of edema associated with heart failure, pulmonary edema, high blood pressure;

    (3) metabolic acidosis pH <7.2;

    (4) complicated by uremic pericarditis, gastrointestinal bleeding, central nervous system symptoms such as trance, drowsiness, coma, convulsions, and psychiatric symptoms.

    Second, early dialysis indications: uremia progress quickly obvious deterioration in general condition, severe gastrointestinal symptoms, and can not eat, malnutrition; concurrent peripheral neuropathy; red blood cell volume in 15%; diabetic nephropathy, kidney disease of connective tissue disease, old age patients.

    Third, the clinical manifestations of uremia, such as nausea, vomiting, edema, heart failure;

    Above, serum creatinine> 707.2μmmol / L, and endogenous creatinine clearance <10ml/min; uremic nitrogen to 30mmol / L (80mg/d1)

    In addition the experts advise patients to control blood sugar and blood fat,follow a  low-salt diet, limit protein intake, smoking cessation, avoid renal Poison, lifestyle changes, correction of anemia, correction of acidosis, the treatment of renal osteodystrophy, correcting malnutrition, treatment cardiovascular complications and so on. The doctor will accurately determine when to require dialysis treatment, ahead of a comprehensive pre-dialysis missionary. So be sure to actively cooperate with the doctors.
    You may also communicate with free experts online for more about it. 
Related article:
Dangers for Patients with Diabetic Nephropathy on Dialysis

How to Reduce Creatinine Level for Patients with Polycystic Kidney Disease

Creatine is used as a source of energy by your muscles. According to MayoClinic.com, 95 percent of creatine in the body is located in your skeletal system. Too much creatine in your body can lead to muscle cramping or gastrointestinal symptoms such as stomach discomfort, diarrhea and nausea.
creatinine level is usually considered as one of the items that can reflect glomerular filtrating function.
In stage of Polycystic Kidney, cysts are still small and their pressure on kidney is also small. Besides, symptoms usually appear after pathological injury. So creatinine level is normal in this stage. But when creatinine begins to increase, it usually means that kidneys have already been injured.
When the kidneys cannot work efficiently, as with Polycystic Kidney Disease (PKD), creatinine levels may rise. How to lower creatinine effectively?
1. Vegetarian diet: By consuming a largely plant based diet you will be helping your body in a few distinct ways
- Dietary sources of creatine and creatinine are only found within animal products, therefore you will be reducing the burden of “extra” creatine and creatinine circulating through your blood by eating a largely plant based diet.
2. Avoid creatine supplements: not only do high doses of this large molecule cause kidney problems (because of its large size it can cause the kidneys to swell), but by supplying the body with extra creatine, you will cause more creatine to be spontaneously converted to the by-product creatinine.
3. Avoid strenuous physical activity: thereby decreasing the breakdown of creatine into creatinine.
4. Nettle leaf tea: drink 1 to 2 cups a day. Nettle leaf tea is a simple yet powerful kidney tonic that can improve kidney function and reduce serum creatinine levels. (Tip: Double check that it is the leaf and not the root, the leaf if for your kidneys, the root is for male prostate disorders)
5. Avoid the over consumption of Vanadium: Although very beneficial for the body, particularly for diabetes and blood sugar problems, over consumption of the mineral vanadium has been linked to increased blood creatinine levels (stay under 100mcg a day).

Cause Of High Creatinine Levels In Blood

The kidneys are primarily responsible for regulating the levels of creatinine in the blood and any factor that tends to interfere with normal functioning of the kidney can result in elevated levels of creatine in the blood. These factors include,
Kidney dysfunction caused due to azotemia or kidney failure is one of the primary cause of high creatinine levels
Kidney stones and recurrent urinary tract infections may also be responsible for elevated levels of creatinine
Hypertension and diabetes mellitus may also result in impaired kidney functions which in turn may result in elevated levels of serum creatinine
Certain drugs and medications are also responsible for transit rise in the creatinine levels
Consumption of large amount of dietary meat may also result in elevated levels of creatinine which is often transient
Malnutrition may result in excessive breakdown of proteins in the body, which in turn would result in elevated levels of creatinine levels

How to reduce creatinine naturally

Creatinine is a very important source of energy for our body. Obtained from foods and other supplements available from health food stores, creatinine is used by the body to increase levels of energy and the mass of muscles.
However, for cases of over-intake of creatinine supplements may lead to a great increase in its levels in our body. In this case, a person with high creatinine is at great risk to heart and kidney damage, dehydration, and in worst cases, death.
Too much creatine in your body can lead to muscle cramping or gastrointestinal symptoms such as stomach discomfort, diarrhea and nausea. Decreasing creatine can help alleviate these symptoms.
Step 1
Visit your physician. Your physician can run tests and find out if you have creatine allergies or other conditions that require a decrease in creatine levels.
Step 2
Avoid supplementing creatine. Creatine is often used by athletes to improve muscle building and to raises energy during workouts. If you currently take creatine supplements, gradually reduce your intake to give your body time to adapt and return to normal levels.
Step 3
Cut down on red meat intake. Red meats are a natural source of creatine. Fish such as herring, tuna, and salmon all contain substantial amounts. If your diet is high in these types of foods, consider cutting back or eliminating intake. You can replace meat proteins with legumes or whey protein.
Step 4
Drink more water. According to the American College of Sports Medicine, since creatine is excreted in your urine, flushing out your system by drinking more water can help rid your body of excess creatine. Try to drink a minimum of eight, 8-oz. glasses of water per day to help eliminate creatine.

Increased urea and creatinine are mainly caused by renal failure or decreased kidney function. Kidneys work as filters in our body. Filtering the toxins out from our body and cleansnig the blood. If the kidneys are not working properly due to Diabetic nephropathy, Renal artery stenosis (genetic or due to chronic blood pressure) and other kidney diseases like renal cysts, malignancies, tumors, drugs and others.

Can Polycystic kidney disease caused renal failure

Polycystic kidney disease (PKD) is a genetic disorder characterized by the growth of numerous cysts in the kidneys. The kidneys are two organs, each about the size of a fist, located in the upper part of a person's abdomen, toward the back. The kidneys filter wastes and extra fluid from the blood to form urine. They also regulate amounts of certain vital substances in the body. When cysts form in the kidneys, they are filled with fluid. PKD cysts can profoundly enlarge the kidneys while replacing much of the normal structure, resulting in reduced kidney function and leading to kidney failure.
When PKD causes kidneys to fail-which usually happens after many years-the patient requires dialysis or kidney transplantation. About one-half of people with the most common type of PKD progress to kidney failure, also called end-stage renal disease (ESRD). The duration from early stage Polycystic Kidney Disease to end-stage Renal Failure differs in different persons. A good nursing in daily life and timely treatment can all affect the duration. In addition, factors such as infections, not well controlled complications, improper diet, strenuous exercise, drinking or smoking can all aggravate the illness condition or fasten up the deterioration of Polycystic Kidney Disease into Renal Failure.
PKD can also cause cysts in the liver and problems in other organs, such as blood vessels in the brain and heart. The number of cysts as well as the complications they cause help doctors distinguish PKD from the usually harmless "simple" cysts that often form in the kidneys in later years of life.

How to Prevent Renal Failure for Polycystic Kidney Disease?

1. When the kidney is invaded by inflammation or stones the kidney tubules epithelial will appear phenotype transformation and then the permeability of cyst wall decreases so that the cyst liquid secreted by cyst wall can not be discharged out of human body. Then the cyst liquid will accumulate into the cyst which will lead to the increase in size of cysts along with the time passing by. So the key point to treat Polycystic Kidney Disease is to control and shrink the size of cysts and supply new nephrons to play renal function which should have been done by those necrotic nephrons.Keep good moods and avoid overwork. Follow the doctor’s advice. Have a light diet and eat more fruits. Control the intake of protein. It is better for your health to give up smoking and alcohol. When high blood pressure is serous and edema happens, restrict the salt intake. Properly exercise but avoid the extensive exercise.

2.keep a balanced diet
3.Active treatment

Micro-Chinese Medicine Osmotherapy and Immunotherapy is taken to treat Polycystic Kidney Disease, of which the former is used to repair the damaged kidneys by shrnking and controlling the cysts, and the later is applied to regenerate kidney functions by producing new nephrons.the active substance of Micro-Chinese Medicine can restrain the secretion of cyst wall epithelial cell; prevent the continuous expanding of bursa wall vessels and cyst. This therapy fundamentally controls the enlargement of cysts and repairs the damaged renal nephrons.

Blood Plasma Exchange Experimental Research Effects

Truth about blood plasma exchange：
The basic principles of blood component replacement (apheresis) means by centrifugation or a membrane cell separator to eliminate cellular components (such as red blood cells, lymphocytes, white blood cells,platelets, plasma), the other components of transfusion to the patient. The eradication of one liter of plasma, blood decreased plasma protein lg/d1 However, because the balance and protein synthesis compartment, so it is necessary to exchange weekly 2.5 liters of plasma to plasma protein levels. About 509,6 of total IgG and 679/6 of a total of IgM. Nine of the period of three weeks 50mg/kg exchange, leaving only 5% of the original plasma. Eradication of plasma proteins and composition, depending on its charge, solubility, and other plasma protein pro-Heli, structure, synthesis and photo
The rate of incorporation. In the immune disorder, a combination of free inhibitor can slow down the immune globulin recovery. If you do not use of immunosuppressive agents, antibodies in the initial decline is visible after the
Now "antibodies anti-jump" or some of the antibody levels increased rapidly, to achieve blood components set tendency to change the value of the former base level, which is often associated with disease activity. Plasma usually by the United
Application albumin, salt and water replacement. Some of the complications of lupus (such as blood clots bloodBoard purpura) must use the new frozen plasma replacement. Plasmapheresis serious
Complications (such as low blood pressure, irregular heartbeat, infection), low incidence, reportedly less than 3%.
2 The application of  plasma exchange in SLE treatment can eradicate the cycle immune complexes(eg, free antibodies, complement components), changing and achieve great relievings in the patients. 
In a reported plasma exchange improve suppressor cells function in the other reports. Its selective eradication of the anti DNAIgG. Steven and other confirmed in the plasma set. After the change, monocytes kill the bacteria capacity to be improved; in the light disease, Tsokos found on mitosis original proliferative response of lymphocyte subsets percentage of no change. However, Wallace et al reported 17 cases of steroids or immunosuppressive. Inhibitor resistance in patients with lupus nephritis, B cells and T-cell count is normal,but to promote a mitogenic response and CD4 levels dropped after 15 plasmapheresis.